By Douglas J. Martin BS, Edward G. Randles PhD, Marina Ramirez-Alvarado PhD (auth.), Morie A. Gertz, S. Vincent Rajkumar (eds.)
An up to date reference in this attention-grabbing set of advanced issues, this booklet positive factors the main finished innovations for diagnosing, classifying, imaging, treating, and dealing with amyloidosis in a number of organ structures. important to the spectrum of practitioners from citizens to sub-specialists, this publication is a succinct authoritative textual content written by way of leaders within the box. The authors supply guideline on all kinds of amyloidosis - together with basic amyloidosis (AL), secondary amyloidosis (AA), and familial amyloidosis. With crucial therapy algorithms, Amyloidosis: prognosis and remedy is the gold-standard for all hematologists, oncologists, and internists taking good care of sufferers with this disease.
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Extra info for Amyloidosis: Diagnosis and Treatment
2003;44:177–83. 26. Han S, Chong V, Murray T, et al. Preliminary experience of 99mTc-aprotinin scintigraphy in amyloidosis. Eur J Haematol. 2007;79:494–500. 27. Kula RW, Engel WK, Line BR. Scanning for soft-tissue amyloid. Lancet 1977;1:92–3. 28. Falk R, Lee V, Rubinow A, Hood WJ, Cohen A. Sensitivity of technetium99m-pyrophosphate scintigraphy in diagnosing cardiac amyloidosis. Am J Cardiol. 1983;51:826–30. 29. Falk R, Lee V, Rubinow A, Skinner M, Cohen A. Cardiac technetium-99m pyrophosphate scintigraphy in familial amyloidosis.
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The most important context to consider is chronic inflammation. In this setting, the routine search for proteinuria is mandatory to detect AA amyloidosis and an inquiry of the family medical history directs toward a genetic form. AL amyloidosis is difficult to diagnose because it has the highest degree of variety of clinical symptoms and because the context of a plasmacytic disease is not apparent, except the uncommon cases where a monoclonal component is already known. How to Make the Diagnosis of Amyloidosis?